Microbiome and Immunity

Immune responses to antigens are shaped by environmental factors. We study how our immune system interacts with commensal microbes to modulate systemic immune responses. This collaboration between the host immune system and symbionts might reveal fundamental principles of immunity.

Research

Cancer Immunity

Our body cells have the potential to transform into cancerous cells. Our immune cells play a pivotal role in eliminating those abnormal cells. However, cancer cells protect themselves from being destroyed by exploiting various immune mechanisms that induce tolerance. By manipulating this balance, we can more effectively eradicate cancer cells.

Research

Microbiome

Our body is home to trillions of microbes that have co-evolved with the host immune system. They help protect their habitat from foreign threats while avoiding strong immune responses against themselves. By decoding the mutualism, we can invent new therapies to treat diseases.

Research

Welcome to the Park Laboratory

We are a group of scientists who study how commensal microbes residing in our body modulate cancer immunity. Our research integrates the expertise in immunology, microbiology, and cancer biology. Embedded in the unique research environment of the University of Chicago Biological Science Division, the University of Chicago Medicine Hematology and Oncology, Cancer Metabolomics Research Center, the University of Chicago Comprehensive Cancer Center, and Duchossois Family Institute, we aim to develop an innovative approach to uncover novel biology and therapies.